International Association for the Study of Pain®  IASP Press®

(Vienna, Austria, 1999)

Progress in Pain Research and Management, Volume 16
Editors: Marshall Devor, PhD;  Michael C. Rowbotham, MD;  Zsuzsanna Wiesenfeld-Hallin, PhD 
2000, 1160pp, hardbound, ISBN 0-931092-31-0. Special Price: $50.00 US 
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These proceedings cover the entire spectrum of topics contained within the congress theme, "Pain: from Molecule to Mind", and offer a comprehensive overview of the status of pain science and medicine today. Pharmacological, physical, psychological and cognitive approaches to pain management are discussed, as are complementary approaches to pain modulation and the ancillary benefits of pain research. Neuropathic, nociceptive, inflammatory, and sympathetic-related pain are dealt with extensively. Here is an opportunity to view at a glance the entire field of pain science and medicine, and to test and improve your understanding of topics with which all pain professionals should have at least passing familiarity.

Certain sessions are available on audiotape from Averecording Co., Germany.
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Table of Contents

Click on the list below or scroll down to see chapter titles in each of these Parts.

Part I. Pain, IASP, and the Vienna Congress
Part II. Cellular and Molecular Mechanisms: Peripheral and Central Nervous Systems
Part III. Experimental Models of Pain: Peripheral Nervous System
Part IV. Experimental Models of Pain: Central Nervous System
Part V. Genes and Environment
Part VI. Imaging Pain
Part VII. Nociceptive, Inflammatory, and Sympathetic-Related Pain
Part VIII. Neuropathic Pain
Part IX. Pharmacological Approaches to Pain Management
Part X. Physical Approaches to Pain Management
Part XI. Psychological and Cognitive Approaches to Pain Management
Part I. Pain, IASP, and the Vienna Congress

President’s Address to the 9th World Congress on Pain: Basic Researchers and Clinicians Must Unite in the Fight against Pain. J.-M. Besson

Incoming President’s Address: Looking Back, Looking Ahead. B.J. Sessle

Pain in Context: The Intellectual Roots of Pain Research and Therapy. P.D. Wall

Influencing Cancer Pain Management: Medical Writing in the Second Half of the 20th Century. C. Faull

A Web-Based Multidisciplinary Course in Pain Management S. Loftus, I. Taylor, R. Harris, and M. Cousins

Part II. Cellular and Molecular Mechanisms: Peripheral and Central Nervous Systems

The Primary Nociceptor: Special Functions, Special Receptors J.N. Wood, A.N. Akopian, P. Cesare, Y. Din, R. Garcia, M. Heath, A. Liapi, M. Malik-Hall, M. Nassar, K.Okuse, S. Ravenall, O. Rufian, V. Souslova, and M. Sukumaran

ATP (P2X) Receptors and Pain.G. Burnstock, S.B. McMahon, P.P.A. Humphrey, and S.G. Hamilton

Sodium Channels as Molecular Targets in Pain. T.R. Cummins, S.D. Dib-Hajj, J.A. Black, and S.G. Waxman

Ectopic Discharge in Primary Sensory Neurons Depends on Intrinsic Membrane Potential Oscillations.R. Amir, M. Michaelis, and M. Devor

Spontaneous Action Potential Discharge in Cultured Dorsal Root Ganglion Neurons from Patients with Neuropathic Pain T.K. Baumann and M.E. Martenson

Action of the Hyperpolarization-Activated Current Blocker ZD7288 in Dorsal Root Ganglion Neurons Classified by Conduction Velocity J. Yagi, N. Hirai, and R. Sumino

Altered Excitability of Large-Diameter Cutaneous Afferents following Nerve Injury: Consequences for Chronic Pain J.D. Kocsis and M. Devor

The Role of Neighboring Intact Dorsal Root Ganglion Neurons in a Rat Neuropathic Pain Model T. Fukuoka, A. Tokunaga, E. Kondo, and K. Noguchi

The Molecular Biology of Mu Opioid Analgesia G.W. Pasternak

Approaches to the Study of Altered Gene Expression in Pain K. Befort and M. Costigan

Neurotrophic Factor Effects on Pain-Signaling Systems T.J. Boucher, B.J. Kerr, M.S. Ramer, S.W.N. Thompson, and S.B. McMahon

Phosphorylation of ERK and CREB in Nociceptive Neurons after Noxious Stimulation R.-R. Ji, G.J. Brenner, R. Schmoll, H. Baba, and C.J. Woolf

Part III. Experimental Models of Pain: Peripheral Nervous System

Subpopulations of Human C Nociceptors and Their Sensory Correlates E. Torebjörk

Sensory Functions of Epidermal Nerve Fibers in Humans D.A. Simone, N. Khalili, J.-D. Brederson, C. Feder, G. Wendelschafer-Crabb, and W.R. Kennedy

Secondary Hyperalgesia to Punctate Stimuli Is Mediated by A-Fiber Nociceptors E. Jørum, T. Warncke, E.A. Ziegler, W. Magerl, P.N. Fuchs, R.A. Meyer, and R.-D. Treede

The Tingling Sensation of Carbonated Drinks Is Mediated by a Carbonic Anhydrase-Dependent Excitation of Trigeminal Nociceptive Neurons C.T. Simons, J.-M. Dessirier, M. I. Carstens, M. O’Mahony, and E. Carstens

Unidirectional Conduction Block at Branching Points of Human Nociceptive C Afferents: A Peripheral Mechanism for Pain Amplification. C. Weidner, M. Schmelz, R. Schmidt, H.O. Handwerker, and H.E. Torebjörk

Mid-Axonal TNF Causes Allodynia and C-Nociceptor Activity: TNF-Induced Activity Is Blocked by Low-Dose Intravenous Lidocaine. H. Junger, C.M. Doom, and L.S. Sorkin

Pain-Related Behavior in TNF-Receptor-Deficient Mice. C. Vogel, T. Lindenlaub, G. Tiegs, K.V. Toyka, and C. Sommer

Neurogenic Inflammation following Intradermal Injection of Capsaicin Is Partially Mediated by Dorsal Root Reflexes.Q. Lin, J. Wu, and W.D. Willis

Hyperalgesia Generated by the Sympatho-Adrenal System. W. Jänig, S.G. Khasar, J.D. Levine, and F.J.-P. Miao

Blockade of Diabetic, Chemotherapeutic, and NGF-Induced Pain by Antisense "Knockdown" of PN3/SNS, a TTX-Resistant Sodium Channel. F. Porreca, M.H. Ossipov, J. Lai, S. Wegert, D. Bian, S. Rogers, P. Mantyh, S. Novakovic, and J.C. Hunter

The Effect of Lamotrigine and Morphine on Neuropathic Pain in the Rat. S.D. Collins, N.M. Clayton, M. Nobbs, and C. Bountra

Part IV. Experimental Models of Pain: Central Nervous System

What Transgenic Mice Have Taught Us about Pain. A.I. Basbaum

Spinal Substance P Receptor Expression and Internalization in Acute, Short-Term, and Long-Term Inflammatory Pain States. P. Honoré and P.W. Mantyh

Discrepant Results from Preclinical and Clinical Studies on the Potential of Substance P-Receptor Antagonist Compounds as Analgesics. S. Boyce and R.G. Hill

Receptive Field Properties and Spike-Burst Responses to Intracellular Current Injection in Dorsal Horn Neurons. H.-R. Weng and P.M. Dougherty

Differential Spinal Release of Amino Acid Neurotransmitters following Selective Activation of C or Ad Thermo-Nociceptors D.C. Yeomans, Y. Lu, M. Peters, M. Whitely, and C.E. Laurito

Antisense Knockdown of mGluR1 Reverses Hyperalgesia and Allodynia Associated with an Established Neuropathic Injury in Rats M.E. Fundytus, J.L. Henry, A. Dray, and T.J. Coderre

Spinal Cholecystokinin Systems in Two Models of Neuropathic Pain in the Rat M. Pohl, J.M. Antunes-Bras, M.-A. Coudoret, A.-M. Laporte, J.-J. Benoliel, M. Hamon, A. Eschalier, and F. Cesselin

Long-Lasting Analgesia following TENS and Acupuncture: Spinal Mechanisms beyond Gate Control. J. Sandkühler

Multiple Pain Pathways. L. Villanueva and P.W. Nathan

Multiplicity and Plasticity of Descending Modulation of Nociception: Implications for Persistent Pain. K. Ren, M. Zhuo, and W.D. Willis

Quantitative Sensory Testing in Patients with Painful or Painless Syringomyelia. D. Bouhassira, N. Attal, L. Brasseur, and F. Parker

The Ventromedial Thalamus: A Link for Noxious Cutaneous Inputs from the Whole Body Surface. L. Monconduit, L. Bourgeais, J.-F. Bernard, D. Le Bars, and L. Villanueva

Thalamic Stimulation-Evoked Pain and Temperature Sites in Pain and Non-Pain Patients. J.O. Dostrovsky, M. Manduch, K.D. Davis, R.R. Tasker, and A.M. Lozano

Plasticity of the Inhibitory Circuitry of the Primate Ventrobasal Thalamus following Lesions of Somatosensory Pathways. D.D. Ralston, P.M. Dougherty, F.A. Lenz, H.-R. Weng, C.J. Vierck, and H.J. Ralston

Part V. Genes and Environment

Migraine—A Genetic Neurovascular Channelopathy? M.D. Ferrari, E.E. Kors, and G.M. Terwindt

Genetic Correlations among Common Nociceptive Assays in the Mouse: How Many Types of Pain? J.S. Mogil

Angiotensin-Converting Enzyme Gene Polymorphism in Patients with Neuropathic Pain. T. Kimura, T. Komatsu, R. Hosoda, K. Nishiwaki, and Y. Shimada

Pre- but not Postoperative Consumption of Soy Suppresses Pain Behavior following Partial Sciatic Ligation in Rats Y. Shir, J.N. Campbell, S.N. Raja, and Z. Seltzer

Part VI. Imaging Pain

Non-Invasive Brain Imaging during Experimental and Clinical Pain. M.C. Bushnell, G.H. Duncan, B. Ha, J.-I. Chen, and H. Olausson

fMRI of Cortical and Thalamic Activations Correlated to the Magnitude of Pain. K.D. Davis, C.L. Kwan, A.P. Crawley, and D.J. Mikulis

The Cingulate Cortex in Acute and Chronic Pain: H215O, 18FDG, and 11C-Diprenorphine PET Studies. T.R. Tölle, H.J. Wester, M. Schwaiger, B. Conrad, P. Bartenstein, and F. Willoch

Is the Cerebellum Involved in Pain? C.Y. Saab, A.A. Makki, M.J. Quast, J. Wei, E.D. Al-Chaer, and W.D. Willis

Part VII. Nociceptive, Inflammatory, and Sympathetic-Related Pain

Visceral Hyperalgesia. M.A. Giamberardino

Urogenital Pain Syndromes in Men and Women. U. Wesselmann

Role of the Limbic System in Sex, Gender, and Pain. A.M. Aloisi

Altered CNS Processing of Nociceptive Messages from the Vagina in Rats that Have Recovered from Uterine Inflammation. U. Wesselmann, C. Sanders, and P.P. Czakanski

Peripheral and Central Sensitization during Migraine. R. Burstein and A. Strassman

A Systematic Review and League Table of Pharmacological Interventions for Acute Migraine Attack. A.D. Oldman, L.A. Smith, H.J. McQuay, and R.A. Moore

Peripheral Morphine Analgesia in Dental Surgery Patients. M. Schäfer, R. Likar, and C. Stein

Cancer Pain Mechanisms and Animal Models of Cancer Pain. P.W. Wacnik, G.L. Wilcox, D.R. Clohisy, M.L. Ramnaraine, L.J. Eikmeier, and A.J. Beitz

Late Sequelae of Post-Mastectomy Radiotherapy. U.E. Kongsgaard, B. Erikstein, and S. Kvinnsland

Coupling of Sympathetic and Somatosensory Neurons following Nerve Injury: Mechanisms and Potential Significance for the Generation of Pain. M. Michaelis

Immobility in Volunteers Transiently Produces Signs and Symptoms of Complex Regional Pain Syndrome. S.H. Butler, M. Nyman, and T. Gordh

Neurogenic Vasoconstriction in the Dorsal Root Ganglion May Play a Crucial Role in Sympathetic-Afferent Coupling after Spinal Nerve Injury. H.-J. Häbler, S. Eschenfelder, H. Brinker, B. Grunow, X. Liu, and W. Jänig

Does Regional Acute Pain in Humans Alter Regional Sympathetic Discharge? M. Nordin and M. Elam

Part VIII. Neuropathic Pain

Pain Syndromes that May Develop as a Result of Treatment Interventions. P. Marchettini, F. Formaglio, A. Barbieri, L. Tirloni, and M. Lacerenza

Mechanisms of Pain Arising from Spinal Nerve Root Compression. C.R. Morton, G.R. Lacey, and R.L.G. Newcombe

Possible Causes of Pain in Repetitive Strain Injury. J. Greening and B. Lynn

SNS/PN3 and NaN/SNS2 Sodium Channel Immunoreactivity in Human Pain States. K. Coward, G. Saldanha, R. Birch, T. Carlstedt, and P. Anand

Chronic Neuropathic Pain in Leprosy. A. Hietaharju, R. Croft, R. Alam, and M. Haanpää

Acute Pain in Herpes Zoster. R.H. Dworkin, R.W. Johnson, and D.R.J. Griffin

Trigeminal Postherpetic Neuralgia Postmortem: Clinically Unilateral, Pathologically Bilateral. C.P.N. Watson, R. Midha, M. Devor, S. Nag, C. Munro, and J.O. Dostrovsky

Changes in Sodium Channel SNS/PN3 and AnkyrinG mRNAs in the Rat Trigeminal Ganglion following Inferior Alveolar Nerve Injury. U. Bongenhielm, C.A. Nosrat, I. Nosrat, J. Eriksson, and K. Fried

Neurogenic Vasodilatation in Trigeminal Neuralgia. T. Nurmikko, C. Haggett, and J. Miles

Part IX. Pharmacological Approaches to Pain Management

Understanding Clinical Trials: What Have We Learned from Systematic Reviews? R.A. Moore

Spinal Actions of Cyclooxygenase Isozyme Inhibitors. G. Geisslinger and T.L. Yaksh

High-Tech Versus Low-Tech Approaches to Postoperative Pain Management. H. Breivik

A Comparison of the Tolerability of Ibuprofen, Acetaminophen, and Aspirin for Short-Term Analgesia. N. Moore, E. Van Ganse, J.-M. Le Parc, R. Wall, H. Schneid, M. Farhan, F. Verrière, and F. Pelen

Clinical Trials of NMDA-Receptor Antagonists as Analgesics. P.K. Eide

Recent Developments in the Treatment of Neuropathic Pain. M.C. Rowbotham, K.L. Petersen, P.S. Davies, E.K. Friedman, and H.L. Fields

Lamotrigine in the Treatment of Painful Diabetic Neuropathy: A Randomized, Placebo-Controlled Study. Y. Luria, C. Brecker, D. Daoud, A. Ishay, and E. Eisenberg

Effects of Intravenous Lidocaine on Spontaneous and Evoked Pains in Patients with CNS Injury. N. Attal, L. Brasseur, F. Guirimand, M. Dupuy, F. Parker, V. Gaude, and D. Bouhassira

New and Old Anticonvulsants as Analgesics. A.H. Dickenson and V. Chapman

Patient Information Leaflets and Antidepressant Prescription in Chronic Pain Patients. C. Cedraschi, V. Piguet, W. Fisher, A.-F. Allaz, J. Desmeules, and P. Dayer

The Role of Adenosine in the Treatment of Neuropathic Pain. R. Karlsten and T. Gordh

Systemic Adenosine Infusion Reduces the Area of Neuropathic Tactile Allodynia: A Multi-Center, Placebo-Controlled Study. K.-F. Sjölund, M. Belfrage, R. Karlsten, M. Segerdahl, S. Arnér, T. Gordh, and A. Sollevi

Cannabinoids and Pain Modulation in Animals and Humans. A. Holdcroft, K.M. Hargreaves, A.S.C. Rice, and R.G. Pertwee

The Contribution of the Cannabinoid CB1 Receptor to Spinal Nociceptive Processing. V. Chapman

Efficacy of Permanent Indwelling Catheters Used for Regional Analgesia. D. Niv, P.P. Raj, and S. Erdine

Infection Rates in Patients with Long-Term Intrathecal Infusion of Opioids and Bupivacaine. P. Dahm, C. Lundborg, M. Jansson, C. Olegård, P. Nitescu, I. Curelaru, and L. Appelgren

A Prospective, Open Study of Oral Methadone in the Treatment of Cancer Pain. E. Bruera, M.A. Rico, M. Bertolino, J.R. Moyano, S.R. Allende, R. Wenk, C. M. Neumann, and J. Hanson

Opioids in Chronic Nonmalignant Pain: A Criteria-based Review of the Literature. S. Graven, H.C.W. de Vet, M. van Kleef, and W.E.J. Weber

Preemptive Analgesia: How Can We Make it Work? I. Kissin

Part X. Physical Approaches to Pain Management

Development of an Active Placebo for Studies of TENS Treatment. M.-C. Chakour, S.J. Gibson, M. Neufeld, Z. Khalil, and R.D. Helme

Epidural Spinal Cord Stimulation for Treatment of Chronic Pain: Some Predictors of Success. Bettaglio, and M. AllegriC. Bonezzi, M. Barbieri, L. Demartini, D. Miotti, L. Paulin, R.

Coronary Artery Bypass Grafting Versus Spinal Cord Stimulation in Severe Angina Pectoris: Further Results from the ESBY Study. Eliasson, and C. MannheimerH. Norrsell, M. Pilhall, T.

Motor Cortex Stimulation for Chronic Neuropathic Pain. D. Carroll, C. Joint, T. Aziz, and H. McQuay

Physical Therapy Assessment: Expanding the Model. M.J. Simmonds, V. Harding, P.J. Watson, and Y. Claveau

Differences between Patients with Fibromyalgia and Patients with Chronic Musculoskeletal Pain. Biasi, P. Castrogiovanni, and R. MarcolongoG. Carli, A.L. Suman, F. Badii, V. Bachiocco, G. Di Piazza, G.

No Influence of Naloxone on the Initial Hypoalgesic Effect of Spinal Manual Therapy. B. Vicenzino, J. O’Callaghan, F. Kermode, and A. Wright

Part XI. Psychological and Cognitive Approaches to Pain Management

Charisma and the Art of Healing: Can Nonspecific Factors Be Enough? R.H. Gracely

Can Cognitive-Behavioral Therapies Succeed Where Medical Treatments Fail? F.J. Keefe

Factors That Determine the Magnitude and Presence of Placebo Analgesia. D.D. Price

Attitudinal Barriers to Effective Pain Management in the Nursing Home. D.K. Weiner and T.E. Rudy

Self-Efficacy as a Mediator of Depression and Pain-Related Disability in Chronic Pain. P. Arnstein, M. Caudill, and C. Wells-Federman

Solicitousness Revisited: A Qualitative Analysis of Spouse Responses to Pain Behaviors. T.R.O. Newton-John and A.C. de C. Williams

Talking to Others about Pain: Suffering in Silence. S. Morley, K. Doyle, and A. Beese


    Readers are invited to study this volume for its broad perspective on the magnitude of suffering caused by untreated pain. Taken as a whole, the text provides a phenomenal review of the various organ systems and biological molecules involved in the genesis and maintenance of pain. Therefore, students of pain research or practitioners interested in singular types of pain will find this work illuminating and analytical. This volume is a heroic effort to develop a better understanding of the pathogenesis of chronic pain with an eye toward using this information to develop better treatments. Even today, neuropathic and other chronic pains are commonly refractory to standard treatments. Often, patients report that they lack adequate relief, or they stop their regimens due to adverse effects of therapies that outweigh any perceived benefit. It is the hope of the contributors to this effort that we can better define such pain states, and ultimately shift the balance of therapy to provide greater relief with fewer adverse consequences. The Annals of Pharmacotherapy

     This important publication contains the best of the of the presentations at the Triennial World Congress on Pain, the largest and most prestigious of congresses on pain therapy and science. [It] is the most up-to-date compendium of knowledge on pain in existence, and represents an essential item for any pain clinician’s library. British Journal of Anaesthesia     

    With the high standard and diversity of presentations usually prominent in the scientific sessions [of the triennial congresses], it is a daunting and unenviable task to collate this material into a broadly appealing format. This, however, the editors have managed to achieve in admirable fashion.
    Broadly sectioned into physiologically relevant areas, the key abstracts begin with cellular and molecular mechanisms of pain production and move sequentially through the experimental models for the peripheral and central nervous systems. Whilst this is essentially a setting for basic scientists, there is much of interest to bedside clinicians.
    Moving into the more clinical chapters, there is a great deal of material applicable to everyday problems in clinical pain, especially neuropathic pain syndromes and the complementary investigative medium of brain imaging
    Chronic and malignant pain conditions receive the lion’s share of the text, but in a balanced fashion that is relevant to most pain practitioners. Pathophysiological mechanisms are nicely interwoven with clinical trials and outcomes so that a common thread is maintained. Adequate weight is also given to the psychological and behavioural components of the pain experience to emphasise the importance of the multidisciplinary contribution to pain research and management.
    This particular edition complements those which have preceded it. It summarises and reflects the current views and directions that interested practitioners must pursue in order to have a better perception of the enigma that is pain. Whilst on par with temazepam for easy bed-time reading, it is nonetheless an essential addition to any major library or reference facility and is a worthy successor to the earlier excellent IASP publications. Anaesthesia and Intensive Care

   2000, 1160pp, hardbound, ISBN 0-931092-31-0. Price: $80.00 US [IASP members: $52.00 US] 

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