International Association for the Study of Pain®    IASP Press®

Editors: Kim J. Burchiel and Robert P. Yezierski

2002 · Hardbound · 440 pages · ISBN 0-931092-43-4
Price: US$89.00 (US$67.00 for IASP members)

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Among the most pressing challenges in SCI research is improving the quality of life for those afflicted with SCI so that they may return to the workplace, re-establish connections with family and friends, and reduce their need for debilitating pharmacotherapy. To this end, the contributors to this volume – all distinguished members of the international pain management community – offer new insights into understanding the underlying mechanisms of SCI pain as well as its treatment. Spinal Cord Injury Pain provides a state-of-the-art assessment of the clinical characteristics, central mechanisms, and treatment strategies of the most common SCI pain states. It recommends future directions of clinical and basic research to improve our understanding and treatment of SCI pain syndromes.

Table of Contents

Part I Clinical Characteristics and Assessment

1. Pain after Spinal Cord Injury. John D. Loeser
2. Taxonomy and Epidemiology of Spinal Cord Injury Pain.
Philip J. Siddall, Robert P. Yezierski, and John D. Loeser
3. Classification of Spinal Cord Injury Pain: Literature Review and Future Directions.
Bret L. Hicken, John D. Putzke, and J. Scott Richards
4. Assessment of Pain and Sensory Abnormalities in Patients with Spinal Cord Injury.
Ellen Jørum
5. Evaluation of Clinical Characteristics of Pain and Psychosocial Factors after Spinal Cord Injury.
Eva G. Widerström-Noga

Part II Experimental Studies

6. Possible Mechanisms of Central Neuropathic Pain. William D. Willis
7. Pathophysiology and Animal Models of Spinal Cord Injury Pain.
Robert P. Yezierski
8. Assessment of Pain Sensitivity in Dermatomes Caudal to Spinal Cord Injury in Rats.
Charles J. Vierck, Jr., and Alan R. Light
9. Mechanisms of Increased Pain Sensitivity within Dermatomes Remote from an Injured Segment of the Spinal Cord.
Charles J. Vierck, Jr., Richard L. Cannon, Kristin A. Stevens, Antonio J. Acosta-Rua, and Edward D. Wirth, III

10. Physiological and Pharmacological Characterization of a Rat Model of Spinal Cord Injury Pain after Spinal Ischemia.  Xiao-Jun Xu, Jin-Xia Hao, and Zsuzsanna Wiesenfeld-Hallin
11. Pharmacology of Chronic Pain after Spinal Cord Injury: Novel Acute and Chronic Intervention Strategies.
Claire E. Hulsebosch 
12. Plasticity in Supraspinal Viscerosomatic Convergent Neurons following Chronic Spinal Cord Injury. Richard D. Johnson and Charles H. Hubscher
13. Microelectrode Studies of the Thalamus in Patients with Central Pain and in Control Patients with Movement Disorders.
S. Ohara, I. Garonzik, S. Hua, and F.A. Lenz
14. New and Old Thoughts on the Mechanisms of Spinal Cord Injury Pain.
A.D. (Bud) Craig

Part III Imaging

15. Understanding Central Pain: New Insights from Forebrain Imaging Studies of Patients and of Animals with Central Lesions. Thomas J. Morrow and Kenneth L. Casey
16. Cortical Pathophysiology of Neuropathic Pain: Human Brain Imaging Studies and Theories of Neuropathic Pain.
A. Vania Apkarian
17. Proton Magnetic Resonance Spectroscopy following Spinal Cord Injury: Evaluation of Patients with Chronic Neuropathic Pain
. Pradip M. Pattany, Eva G. Widerström-Noga, B.C. Bowen, A. Martinez-Arizala, B.R. Garcia, E. Cuevo, R.M. Quencer,and Robert P. Yezierski
18. Correlation of MRI Findings with Spinal Cord Injury Pain following Neural Tissue Grafting into Patients with Post-Traumatic Syringomyelia.  
      Edward D. Wirth, III, Charles J. Vierck, Jr., Paul J. Reier, Richard G. Fessler, and Douglas K. Anderson

Part IV Treatment

19. Clinical Trials for Spinal Cord Injury Pain. Jennifer Haythornthwaite and Stephen Wegener
20. Pharmacological Treatment of Spinal Cord Injury Pain.
Nanna B. Finnerup, I.L. Johannesen, Søren H. Sindrup, Flemming W. Bach, and Troels S. Jensen
21. Spinal Drug Administration in the Treatment of Spinal Cord Injury Pain.
Philip J. Siddall
22. Glutamate Receptor Antagonists in Central Neuropathic Pain following Spinal Cord Injury.
Christine N. Sang
23. Examples of the Use of Gabapentin in the Treatment of Spinal Cord Injury Pain.
Timothy J. Ness, John D. Putzke, Hong-Gang Liu, and James M. Mountz
24. Topiramate in the Management of Spinal Cord Injury Pain: A Double-Blind, Randomized, Placebo-Controlled Pilot Study.
R. Norman Harden, Ephraim Brenman, Samuel Saltz, and Timothy T. Houle
25. Dorsal Root Entry Zone Coagulation in the Management of Spinal Cord Injury Pain.
John P. Gorecki

Part V The Future

26. Future Directions for the Study and Treatment of Spinal Cord Injury Pain. Robert P. Yezierski and Kim J. Burchiel


    [The] book contains 26 chapters, with nearly 60 named contributors. In spite of this the result is a comprehensive and extremely solid basis for its use as a reference source for many clinical and research interests …. The chapter on psychosocial influences (Widerström-Noga) is extremely comprehensive, including as it does the various inventories considered necessary to identify and manage these factors.
This is an important reference book that should be available to all neuroscientific interests.
British Journal of Neurosurgery

    Pain management remains a challenge for every clinician who cares for individuals with spinal cord injury (SCI). A comprehensive resource like this one, which is devoted exclusively to this secondary complication, is certain to attract the attention of the community of SCI professionals.
This book is extremely useful as a "one-step" reference regarding this important aspect of long-term care of patients living with SCI. I found the review of current interventions in section 4 extremely helpful. This included reports of newer medications [such as topiramate] and surgical procedures (dorsal root entry zone coagulation). Spinal Cord Injury Pain: Assessment, Mechanisms, Management should be added to the libraries of professionals in SCI medicine. The Journal of Spinal Cord Medicine

    This book is an excellent example of an effort to bring together clinical researchers and basic scientists on a single topic: pain in persons with spinal cord injury (SCI).
    [It includes the discussion of] a new taxonomy developed by the IASP Task Force on Pain Following Spinal Cord Injury. [T]he new taxonomy attempts to be inclusive of all types of pain and combines acute pain, such as headache caused by acute episodes of autonomic dysreflexia, with chronic pain that may occur below the level of a lesion.
Overall, the book contains thorough discussions of mechanisms of research findings in the area of SCI pain. It is well manufactured and has a useful index. Clinicians who manage patients with SCI, and indeed any physician managing patients with chronic pain, will find this book fascinating and useful.
APS Bulletin

    The book is an essential read for specialists in spinal cord care, for pain specialists in tertiary care centres who may occasionally treat patients with SCI and for anyone who is interested in the fundamental mechanisms of neuropathic pain. British Journal of Anaesthesia, 89 (5): 802-5 (2002)

2002 · Hardbound · 440 pages · ISBN 0-931092-43-4. Price: US$89.00 (US$67.00 for IASP members)

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This page was updated on July 9, 2003