International Association for the Study of Pain®    IASP Press®

Progress in Pain Research and Management, Vol. 21

Editors: Per T. Hansson,  Howard L. Fields,  Raymond G. Hill,  Paolo Marchettini

2001 · Hardbound · 288 pages · ISBN 0-931092-38-8
Price: US$79.00 (US$55.00 for IASP members

Table of Contents               Reviews              Order Form                    IASP

    Although neuropathic pain has been explored extensively both clinically and experimentally, we still encounter significant shortcomings in treatment outcomes. To a great extent, lack of confidence in predicting outcomes arises from our fragmentary understanding of the pathophysiological mechanisms underlying the onset and maintenance of neuropathic pain.  
In this volume, internationally recognized scientists and clinicians provide an up-to-date review of the diagnosis and treatment of neuropathic pain. Topics covered include the latest clinical treatment trials, the neurobiology and clinical relevance of animal models, and the use of sensory testing techniques in patients for addressing issues of pain mechanism. Bringing clinicians and scientists together to address problems of common interest enhances the value of this volume. The reader will be updated on progress in understanding the mechanisms underlying various neuropathic pain conditions. In addition, this conjunction of scholars will favor the development of treatments tailored to these mechanisms. The progress documented in this volume is encouraging, and it is a direct result of expanded interest in the problem in both the scientific and clinical communities.

Table of Contents

1.    Aspects of Clinical and Experimental Neuropathic Pain: The Clinical Perspective. Per T. Hansson, Marco Lacerenza, and Paolo Marchettini

2.    Sodium Channels as Therapeutic Targets in Neuropathic Pain.
      Joel A. Black, Sulayman Dib-Hajj, Theodore R. Cummins,Kenji Okuse, Mark Baker, John N. Wood, and Stephen G. Waxman

3.    Cytokines and Neuropathic Pain. Claudia Sommer

4.    Human Studies of Primary Nociceptors in Neuropathic Pain. Jordi Serra, José Ochoa, and Mario Campero

5.    Central Nervous System Mechanisms of Pain in Peripheral Neuropathy. Anthony H. Dickenson, Elizabeth A. Matthews, and Rie Suzuki

6.    Tonic Descending Facilitation as a Mechanism of Neuropathic Pain.
       Michael H. Ossipov, Josephine Lai, T. Philip Malan, Jr.,Todd W. Vanderah, and Frank Porreca

7.    The Role of the Sympathetic Nervous System in Neuropathic Pain: Clinical Observations and Animal Models. Wilfrid Jänig and Ralf Baron

8.    Postherpetic Neuralgia: A Model for Neuropathic Pain? Turo J. Nurmikko

9.    Antidepressants in the Treatment of Neuropathic Pain. Søren H. Sindrup and Troels S. Jensen

10.    Anticonvulsants and Antiarrhythmics in the Treatment of Neuropathic Pain Syndromes. Miroslav Backonja

11.    Efficacy of Opioids in Neuropathic Pain. Michael C. Rowbotham

12.    Topical Local Anesthetics for Neuropathic Pain. C. Peter N. Watson

13.    Central Nervous System Stimulation for Neuropathic Pain. Bengt Linderoth and Björn A. Meyerson

14.    Neuropathic Pain: The Near and Far Horizon. Howard L. Fields and Raymond G. Hill



Most of the chapters present an extensive review of the literature on the topic under consideration. The initial chapters deal with pathophysiology of neuropathic pain at the molecular level, focusing on the role of sodium channels and cytokines. The meat of the book is dedicated to discussion of peripheral as well as central sensitization mechanisms of chronic pain maintenance, based on hypotheses and conclusions derived from animal in vitro models and neurobehavioural studies, and limited human studies.
… I found the chapter on CNS stimulation to be a concise and clear description of a complex treatment modality that should be a must read for all pain practitioners, whether or not they provide such service. 
Overall, I think an avid pain researcher and practitioner will be delighted with the wealth of literature presented and referenced in this book, although it may be frustrating to a wider audience who may prefer more rapidly accessible learning material on a topic. Canadian Journal of Anesthesia


What I liked about this book was that it allows the reader to compare the views from various researchers, thereby enabling the clinician to gain an understanding of the controversies in research. It is also useful for the specialist in pain management to read. Anaesthesia and Intensive Care

    This compact book is the latest of a series of definitive publications from the International Association for the Study of Pain (IASP ... The series of publications entitled Progress in Pain Research and Management has become an important body of work; it is a key source ofup-to-date and authoritative information ...
[T]his short book was a pleasure to read and hugely informative. It is a timely update and recommended reading for all those working in the pain field, both basic scientists and clinicians.
British Journal of Anaesthesia

    This book is a compendium of presentations made at two satellite meetings to the 1999 IASP Congress in Vienna. It has an all-star cast of authors and addresses both research and clinical aspects of neuropathic pain. The initial chapter by Hansson, Lacerenza, and Marchettini sets the limits for the subsequent chapters by addressing issues in definition, treatments, and experimental models. Subsequent chapters cover the experimental data regarding sodium channels, cytokines, functions of human primary nociceptors, proposed mechanisms of central nervous system plasticity, tonic descending facilitation, the sympathetic nervous system, and mechanisms in postherpetic neuralgia. Next comes a series of chapters on the treatments of neuropathic pain including antidepressants, anticonvulsants, opioids, topical local anesthetics, and electrical stimulation of the central nervous system. The final chapter is an elegant synthesis by Fields and Hill that describes the current state of scientific and clinical knowledge about neuropathic pain andmakes some provocative statements about future developments.
There is a useful index and the book is nicely produced. The price is relatively low, in keeping with the goal of aiding in the dissemination of information about apin and its treatment. The understanding of the mechanisms underlying neuropathic pain states seems to be rapidly expanding, although new treatment strategies have yet to reach the marketplace. This is a useful book to serve as a starting point for learning about this important facet of chronic pain. 
APS Bulletin


2001 · Hardbound · 288 pages · ISBN 0-931092-38-8 · Price: US$79.00 (US$55.00 for IASP members)

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This page was updated on February 19, 2003