International Association for the Study of Pain®    IASP Press®

Hyperalgesia: Molecular Mechanisms 
and Clinical Implications

Table of Contents                      Order Form                   IASP


Progress in Pain Research and Management, Volume 30

 Editors:  Kay Brune, MD and H. Handwerker, MD 

 2004 ·  397 pages ·  hardbound ·  ISBN 0-931092-50-7

Price:  US$89.00 (IASP members US$71.00)

    All health care professionals dealing with pain states are concerned with hyperalgesia. For the basic scientist, hyperalgesia is a fascinating consequence of the plasticity of the nociceptive nervous system. Our knowledge on the pathomechanisms of different forms of hyperalgesia has greatly increased during recent years. Refined analysis methods have provided new insights at all levels of the nervous system—from primary afferents to cortical processing. Methods of molecular biology have allowed for analysis at the level of genomic processing, with fascinating consequences for the study of drug actions. Because of their great impact for the future development of the field, these recent advances are of interest to everybody in the pain field

Table of Contents:

Part I: The Nomenclature of Hyperexcitability

Hyperalgesia and Allodynia: Taxonomy, Assessment, and Mechanisms
R.-D. Treede, H.O. Handwerker, U. Baumgärtner, R.A. Meyer, and W. Magerl



Part II: Molecular Basis of Nociceptive Transduction
Introduction K. Brune

Mechanisms of Hyperalgesia: Regulation of Nociceptor Activation and Excitability. 
J.N. Wood, B. Abrahamsen, M.D. Baker, J.D. Boorman, E. Donier, L. Drew, M.A. Nassar, K. Okuse, L.C. Stirling, and J. Zha

Inflammatory Signals to TRPV1. B.M. Kim and U. Oh

Molecular Mechanisms of TRPV1-Mediated Thermal Hypersensitivity 
M. Tominaga, M. Numazaki, T. Iida, T. Moriyama, T. Sugiura, K. Togashi, T. Higashi, N. Murayama, T. Tominaga, and K. Mizumura

Modulation of TRPV1 by Protein Kinase A C. Nau and M. Kress

Neuroimmunology and Pain: Peripheral Effects of Proinflammatory Cytokines M. Kress and C. Sommer



Part III: Hyperalgesia as a Consequence of Nociceptor Plasticity
Introduction. H.O. Handwerker

Hyperalgesia to Cold in Persistently Inflamed Rats: Changes in C-Fiber-Receptor Activities and Cold-Sensitive Ion Channel Expression. K. Mizumura, K. Takahashi, and J. Sato

Visceral Hypersensitivity. G.F. Gebhart, R. Kuner, R.C.W. Jones, and K. Bielefeldt

ASIC3 Mediates Mechanical Hyperalgesia Induced by Muscle Injury. 
K.A. Sluka, R. Radhakrishnan, M.P. Price, and M.J. Welsh

Sensocrine Function of Capsaicin-Sensitive Nociceptors Mediated by Somatostatin Regulates against Inflammation and Hyperalgesia. J. Szolcsányi, E. Pintér, and Z. Helyes

Tumor-Peripheral Nerve Interactions in a Model of Cancer Pain. D.A. Simone and D.M. Cain



Part IV: Hyperalgesia as a Consequence of Peripheral Input and Central Processing
Introduction. K. Brune

Mechanisms of Secondary Hyperalgesia: A Role for Myelinated Nociceptors in Punctate Hyperalgesia. R.A. Meyer and R.-D. Treede

Transganglionic Transport of Choleragenoid by Injured C Fibers to the Substantia Gelatinosa: Relevance to Neuropathic Pain and Hyperalgesia. G. Jancsó and P. Sántha

Uninjured Afferents and Neuropathic Pain 
M. Ringkamp, B. Shim, G. Wu, B.B. Murinson, J.W. Griffin, and R.A. Meyer

Central Sensitization of Spinothalamic Tract Cells Is a Spinal Cord Form of Long-Term Potentiation W.D. Willis

Involvement of CGRP in Nociceptive Processing and Hyperalgesia: Effects on Spinal and Dorsal Root Ganglion Neurons. H.-G. Schaible, G.Segond von Banchet, A. Ebersberger, and G. Natura

Referred Visceral Hyperalgesia: From Sensations to Molecular Mechanisms. 
F. Cervero and J.M.A. Laird

The Dual Role of the Nitric Oxide/cGMP Pathway in Spinal Nociception 
G. Geisslinger, A. Schmidtko, E. Niederberger, and I. Tegeder

Glycinergic Neurotransmission and the Control of Spinal Hyperalgesia. 
H.U. Zeilhofer, S. Ahmadi, A. Lauterbach, and S. Lippross

Sensitization in Animal Models of Radiculopathic Pain J.M. Cuellar and E. Carstens



Part V: The Role of the Brain in Hyperalgesia
Introduction H.O. Handwerker

Persistent Inflammatory Nociception and Hyperalgesia: Implications for Opioid Actions in the Brainstem and Spinal Cord. D.L. Hammond

Insights from the Thermal Grill on the Nature of Pain and Hyperalgesia in Humans A.D. (Bud) Craig

Distinguishing Nociception from Pain and Hyperalgesia with Percept-Related fMRI. K.D. Davis

Brain-Imaging Studies of Experimental and Clinical Forms of Allodynia and Hyperalgesia. 
R. Kupers, N. Witting, and T.S. Jensen

Allodynia due to Forebrain Sensitization Demonstrated by Thalamic Microstimulation. 
S. Ohara, N. Weiss, S. Hua, W. Anderson, C. Lawson, J.D. Greenspan, N.E. Crone, and F.A. Lenz
Myogenous Temporomandibular Disorder: A Persistent Pain Condition Associated with Hyperalgesia and Enhanced Temporal Summation of Pain. W. Maixner



2004 ·  397 pages ·  hardbound ·  ISBN 0-931092-50-7

Price:  US$89.00 (IASP members US$71.00)


Order Form

For additional information:
IASP Secretariat
909 NE 43rd St., Suite 306
Seattle, WA 98105-6020, USA
Tel: 206-547-6409
Fax: 206-547-1703
WWW: and

Page updated: August 11, 2004