The Pain System in Normal 
and Pathological States: 
A Primer for Clinicians

Progress in Pain Research and Management, 
Volume 31

Luis Villanueva
Anthony Dickenson
Hélène Ollat

2004  :  hardbound :  347 pages  : 70 figures : 
ISBN 0-931092-53-1
US$71.00  (IASP members US$57.00) 

Table of Contents                               Order Form                           IASP      

The last decade has seen much progress in understanding the mechanisms of pain, and advances in basic science have seen translational research leading to volunteer studies and clinical trials. Despite this drawing together of molecules and maladies, the basic science can appear overly complex and impenetrable for clinicians. This book aims to cover key topical molecular, anatomical, physiological, and pharmacological studies on the basic science in a straightforward and accessible manner for all medical and allied professionals with an interest in pain. The book is dedicated to Jean-Marie Besson, who has always attempted to further dialogue between clinicians and basic scientists.

Table of Contents

Part I: Nociceptive Inputs to the Dorsal Horn

Molecular Mechanisms of Noxious Mechanosensation. Liam J. Drew and John N. Wood

Thermal Sensitivity of Sensory Neurons. Martin Koltzenburg

Peripheral Mechanisms of Allodynia and Other Forms of Hyperalgesia in Human Skin. Hermann O. Handwerker and Martin Schmelz


Part II: Dorsal Horn Plasticity following Injury

Molecular Approaches to the Study of Pain. Stephen P. Hunt

Balancing Excitations and Inhibitions in Spinal Circuits. Anthony H. Dickenson, Rie Suzuki,
Elisabeth A. Matthews, Wahida Rahman, Catherine Urch, Lucinda Seagrove, and Lars Rygh

Brainstem Modulation of Pain after Inflammation. Ronald Dubner and Ke Ren


Part III: Anatomical and Functional Organization of Ascending Pain Pathways

Molecular Approaches to Understanding the Anatomical Substrates of Nociceptive Processing. Allan I. Basbaum

Brainstem and Pain: A Complementary Role with Regard to the Thalamus? Jean-François Bernard and Caroline Gauriau

Spinothalamocortical Processing of Pain. William D. Willis, Jr.

Forebrain Responses in Normal and Pathological Pain States: Implications for Therapy. Kenneth L. Casey, Thomas J. Morrow, and Jürgen Lorenz


Part IV: Endogenous Modulatory Systems: Their Role in Analgesia and Pain

The Role of the Sympathetic Nervous System in Pain Processing. Ralf Baron and Wilfrid Jänig

Sensitization of Trigeminovascular Neurons and Migraine Therapy with Triptans.
Rami Burstein, Itay Goor-Aryeh, and Moshe Jakubowski

Endogenous Central Mechanisms of Pain Modulation. Luis Villanueva and Howard L. Fields


Part V: Novel Therapeutic Strategies: Preclinical and Clinical Approaches

Can the Evaluation of Drugs in Animal Pain Models Reliably Predict the Ability to Produce Clinical Analgesia? Raymond G. Hill

Bone Cancer Pain: Mechanisms and Potential Therapies. Patrick W. Mantyh

Neuropathic Pain: Sensory Loss, Hypersensitivity, and Spread of Pain. Troels S. Jensen and Nanna Finnerup

Novel Strategies for Neuropathic Pain. Didier Bouhassira and Nadine Attal

Novel Strategies for Modern Neurosurgery
Jean-Paul Nguyen, Jean-Paul Lefaucheur, K. Moubarak, Pierre Cesaro, S. Palfi, and Yves Keravel

Pain Matters: A Clinical Viewpoint. Henry J. McQuay

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Page updated: October 12, 2004