International Association for the Study of Pain®    IASP Press®

Progress in Pain Research and Management, Vol. 22

R. Norman Harden, MD, Ralf Baron, Dr med, Wilfrid Jänig, Dr med

2001 · Hardbound · 338 pages · ISBN 0-931092-41-8
Price: US$78.00 (US$55.00 for IASP members

Table of Contents               Reviews              Order Form                   IASP

Pain associated with dysfunction of the autonomic nervous system has baffled clinicians and basic scientists alike. Its rich and complicated history continues to unfold within the context of a continuously expanding body of knowledge drawn from many disciplines. This volume illuminates the most recent advances in the study of the mechanisms underlying Complex Regional Pain Syndrome and sheds new light on approaches to diagnosis.

The complexity of this syndrome presents a challenge to both scientists and clinicians, and its management requires a multidisciplinary approach. The symposium that generated Complex Regional Pain Syndrome brought together a broad spectrum of internationally renowned specialists from diverse backgrounds, each of whom provides a piece of the overall puzzle. By integrating these contributions skillfully, the editors present a cohesive overview of the current status of CRPS research and diagnosis. The material presented in this book documents the latest knowledge available in our understanding of CRPS and introduces new diagnostic approaches. It will contribute to the development of new treatment strategies.

Table of Contents

Part I:   Overview  

CRPS-I and CRPS-II: A Strategic View.  Wilfrid Jänig

Part II:  Animal Models

Sympathetic Involvement in the Spinal Nerve Ligation Model of Neuropathic Pain. Kyungsoon Chung and Jin Mo Chung

The Role of Injured and Uninjured Afferents in Neuropathic Pain. Matthias Ringkamp and Gang Wu

Neuropathy after Spinal Nerve Injury in Rats: a Model for Sympathetically Maintained Pain?
Heinz-Joachim Häbler and Wilfrid Jänig

A Model of CRPS-I Produced by Tetanic Electrical Stimulation of an Intact Sciatic Nerve in the Rat: Genetic and Dietary Effects.
Jean-Jacques Vatine, Jeanna Tsenter, Pnina Raber, and Ze’ev Seltzer

The Value of Animal Models in Research on CRPS. Wilfrid Jänig and Ralf Baron

Part III: Human Experimentation

The Role of the Sympathetic Nervous System in Autonomic Disturbances and "Sympathetically Maintained Pain" in CRPS.
Gunnar Wasner, Peter Drummond, Frank Birklein, and Ralf Baron

Kinematic Analysis of the Upper Extremity in CRPS
Jörn Schattschneider, Roland Wenzelburger, Günther Deuschl, and Ralf Baron

Grip Force Coordination in CRPS
Roland Wenzelburger, Jörn Schattschneider, Gunnar Wasner, Jan Raethjen, Henning Stolze, Guenther Deuschl, and Ralf Baron

Motor Abnormalities in CRPS: A Neglected but Key Component. Bradley S. Galer and R. Norman Harden

Disuse and CRPS. Stephen Butler

A Prospective Clinical Model for Investigating the Development of CRPS.
Steven P. Stanos, Jr., R. Norman Harden, Lynne Wagner-Raphael, and Samuel L. Saltz

Human Models of Hyperalgesia Induced by Capsaicin: A Discussion of Secondary Hyperalgesia to Heat.
Ole K. Andersen, Aysen Yucel, and Lars Arendt-Nielsen

The Role of an Exaggerated Regional Inflammatory Response in the Pathophysiology of CRPS. Lijckle van der Laan and R. Jan A. Goris

Clinical Evidence of Central Sensory Disturbances in CRPS. Oliver Rommel and Mark Thimineur

Imaging Brain Pathophysiology of Chronic CRPS Pain. A. Vania Apkarian, Igor D. Grachev, Beth R. Krauss, and Nikolaus M. Szeverenyi

Genetic Considerations in CRPS. Angela Mailis and Judith A. Wade

Human Experimentation. Ralf Baron and Wilfrid Jänig

Part IV: Diagnosis

Reliability of Assessment of Motor Function and Swelling in Patients with Chronic CRPS-I of the Upper Extremity. Pieter U. Dijkstra and Jan H.B. Geertzen

Regional Anesthesia as a Diagnostic Tool for CRPS. Michael Stanton-Hicks

Do Psychological Factors Play a Role in the Onset and Maintenance of CRPS-I? Stephen Bruehl

CRPS: Impact of the Change in Taxonomy. Michael Stanton-Hicks

An Empirical Approach to Modifying IASP Criteria for CRPS. Stephen Bruehl and R. Norman Harden

Diagnosis of CRPS: Summary. R. Norman Harden and Michael Stanton-Hicks

Part V: Epilogue

Epilogue. Gary J. Bennett


… does this text fulfill the aims of the IASP to "provide timely, high quality, attractive, low cost publications relevant to the problem of pain"? The answer … is unquestionably an affirmative one.
… this text is but another phase of the debate on CRPS. The solution of its cause, its diagnosis and its treatment have yet to be defined. What this text does achieve is to signpost the future directions that researchers should take to develop effective treatments for this difficult condition.
Canadian Journal of Anesthesia

    This volume should be available to those clinicians dealing [with] CRPS … apart from details of neural blockade there is no focus on clinical therapies for CRPS and these must be sought elsewhere. Nevertheless, I found it a stimulating update on the status of research on CRPS which has refreshed my thinking on mechanisms and the basis on which to select therapies for CRPS. British Journal of Neurosurgery

 [This book] presents a comprehensive assessment of current research, indicating where we are now and where further work may lead.
Although the subject matter is broad, the section [on human studies] has been put together well, and the reader is able to concentrate on certain areas of interest without having to skip back and forth between chapters.
The IASP have produced another very good, high-quality book. Our understanding of this condition has improved considerably, and I recommend the book to all those with patients who suffer with CRPS. Hopefully, the next edition will contain a section on significant improvements in treatment. British Journal of Anaesthesia

    [This book] consists of 25 chapters … After an introductory overview by Jänig, it covers animal models, human experimentation, and diagnostic criteria. An epilogue by Gary Bennett summarizes the contents.
    The book is useful as a source of information about complex regional pain syndrome (CRPS); the authors' publications in peer-reviewed journals have, of course, much more depth. As is standard for IASP Press, the book is well indexed and well produced. It is a useful addition to one's personal library.
ASP Bulletin, September/October 2002 (American Pain Society)

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This page was updated on February 19, 2003